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CEM's newest member: Dr. Nick Pannunzio

Dr. Nick Pannunzio

The Center for Epigenetics and Metabolism is pleased to welcome Dr. Nick Pannunzio as our newest center member.

Nick received his PhD from the City of Hope in Genetics and Molecular Biology studying mechanisms of homologous recombination. His post-doctoral training was performed at the University of Southern California where he contributed to the understanding of several biochemical aspects of the non-homologous end-joining DNA repair pathway and how DNA breaks in human B cells can result in chromosomal translocations common in many B cell malignancies. The current focus of the Pannunzio Lab is to understand how DNA sequence and torsional stress combine with endogenous sources of DNA damage to lead to these translocations. One aspect of this research is understanding the role of the B cell specific mutator activation-induced cytidine deaminase (AID) that can deaminate C to U or meC to T. Incorporated U’s are repaired more quickly and efficiently than a T:G mismatch suggesting the latter may be a long-lived DNA lesion prone to additional damage. AID activity at genomic regions that are differentially methylated between patients may be an indicator of vulnerability to the types of DNA damage that can result in genome rearrangements. Thus, this research has direct implications for both predicting and preventing several human malignancies that originate in B lymphocytes. http://www.medicine.uci.edu/hematology/

View Dr. Pannunzio's Faculty Profile